Photoacoustic imaging to probe tumour oxygenation and oxidative stress dynamics (Conference Presentation)

Sarah E. Bohndiek

doi:10.1117/12.2300504

15 March 2018 Photoacoustic imaging to probe tumour oxygenation and oxidative stress dynamics (Conference Presentation)

Sarah E. Bohndiek

Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 104930N (2018) https://doi.org/10.1117/12.2300504
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Hypoxia, or low oxygen partial pressure, is a common feature of many solid tumours, associated with therapy resistance and poor prognosis for cancer patients. This chemical feature of the tumour microenvironment represents an imbalance of blood oxygen supply and tissue oxygen demand. Given the prognostic significance of hypoxia, there is a clinical unmet need to provide validated, non-invasive, imaging biomarkers that can be used to detect and monitor the spatiotemporal distribution of hypoxia at the point of cancer diagnosis and during treatment. In this talk, I will give an overview of how photoacoustic imaging can address this unmet need, providing examples from both preclinical studies in mouse models of cancer and clinical studies in human patients.

Conference Presentation

Citation Download Citation

Sarah E. Bohndiek "Photoacoustic imaging to probe tumour oxygenation and oxidative stress dynamics (Conference Presentation)", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930N (15 March 2018); https://doi.org/10.1117/12.2300504

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