13 February 2018 Monitoring skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing
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Abstract
To monitor skin microvascular dysfunction of alloxan-induced type 1 diabetic mice model. In this work, we used laser speckle contrast imaging and hyperspectral imaging through in vivo skin optical clearing method to simultaneously monitor the noradrenaline-induced response of microvascular blood flow and blood oxygen with the development of diabetes. The main results showed that venous and arterious blood flow steadily decreased without recovery after injecting noradrenaline (NE), furthermore the influence of NE-induced arterious blood oxygen response greatly decreased, especially for 2-weeks and 4-weeks diabetic mice. This study demonstrated that skin microvascular function was a potential research biomarker for early warning in the occurrence and development of diabetes. And it provides a feasible solution to realize visualization of cutaneous microvessels for monitoring microvascular reactivity.
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Wei Feng, Rui Shi, Dan Zhu, "Monitoring skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104931O (13 February 2018); doi: 10.1117/12.2288265; https://doi.org/10.1117/12.2288265
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