19 February 2018 Transurethral illumination probe design for deep photoacoustic imaging of prostate
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Abstract
Photoacoustic (PA) imaging with internal light illumination through optical fiber could enable imaging of internal organs at deep penetration. We have developed a transurethral probe with a multimode fiber inserted in a rigid cystoscope sheath for illuminating the prostate. At the distal end, the fiber tip is processed to diffuse light circumferentially over 2 cm length. A parabolic cylinder mirror then reflects the light to form a rectangular-shaped parallel beam which has at least 1 cm2 at the probe surface. The relatively large rectangular beam size can reduce the laser fluence rate on the urethral wall and thus reduce the potential of tissue damage. A 3 cm optical penetration in chicken tissue is achieved at a fluence rate around 7 mJ/cm2 . For further validation, a prostate phantom was built with similar optical properties of the human prostate. A 1.5 cm penetration depth is achieved in the prostate mimicking phantom at 10 mJ/cm2 fluence rate. PA imaging of prostate can potentially be carried out in the future by combining a transrectal ultrasound transducer and the transurethral illumination.
Conference Presentation
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Min Ai, Min Ai, Tim Salcudean, Tim Salcudean, Robert Rohling, Robert Rohling, Purang Abolmaesumi, Purang Abolmaesumi, Shuo Tang, Shuo Tang, } "Transurethral illumination probe design for deep photoacoustic imaging of prostate", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104940C (19 February 2018); doi: 10.1117/12.2291164; https://doi.org/10.1117/12.2291164
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