19 February 2018 A fast MEMS scanning photoacoustic microscopy system and its application in glioma study
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Abstract
We present a water-proof Microelectromechanical systems (MEMS) based scanning optical resolution Photoacoustic Microscopy (OR-PAM) system and its application in glioma tumor mouse model study. The presented OR-PAM system has high optical resolution (~3 μm) and high scanning speed (up to 50 kHz A-scan rate), which is ideal for cerebral vascular imaging. In this study, the mice with glioma tumor are treated with vascular disrupting agent (VDA). OR-PAM system is utilized to image the cerebral with the whole skull intact before and after the injection of VDA. By image registration, the response of every single blood vessel can be traced. This will provide us deeper understanding of the drug effect.
Conference Presentation
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Renzhe Bi, Renzhe Bi, Ghayathri Balasundaram, Ghayathri Balasundaram, Seungwan Jeon, Seungwan Jeon, Yang Pu, Yang Pu, Hui Chien Tay, Hui Chien Tay, Chulhong Kim, Chulhong Kim, Malini Olivo, Malini Olivo, } "A fast MEMS scanning photoacoustic microscopy system and its application in glioma study", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104942I (19 February 2018); doi: 10.1117/12.2287330; https://doi.org/10.1117/12.2287330
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