19 February 2018 High resolution and deep tissue imaging using a near infrared acoustic resolution photoacoustic microscopy
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Abstract
It is always a great challenge for pure optical techniques to maintain good resolution and imaging depth at the same time. Photoacoustic imaging is an emerging technique which can overcome the limitation by pulsed light illumination and acoustic detection. Here, we report a Near Infrared Acoustic-Resolution Photoacoustic Microscopy (NIR-AR-PAM) systm with 30 MHz transducer and 1064 nm illumination which can achieve a lateral resolution of around 88 μm and imaging depth of 9.2 mm. Compared to visible light NIR beam can penetrate deeper in biological tissue due to weaker optical attenuation. In this work, we also demonstrated the in vivo imaging capabilty of NIRARPAM by near infrared detection of SLN with black ink as exogenous photoacoustic contrast agent in a rodent model.
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Mohesh Moothanchery, Mohesh Moothanchery, Arunima Sharma , Arunima Sharma , Vijitha Periyasamy, Vijitha Periyasamy, Manojit Pramanik, Manojit Pramanik, } "High resolution and deep tissue imaging using a near infrared acoustic resolution photoacoustic microscopy", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104945R (19 February 2018); doi: 10.1117/12.2287838; https://doi.org/10.1117/12.2287838
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