In vivo time-serial evaluation of laser-induced choroidal neovascularization in rats simultaneously using photoacoustic microscopy and optical coherence tomography

Cuixia Dai; Lin Li; Wenlu Liu; Fenghua Wang; Chuanqing Zhou

doi:10.1117/12.2288989

19 February 2018 In vivo time-serial evaluation of laser-induced choroidal neovascularization in rats simultaneously using photoacoustic microscopy and optical coherence tomography

Cuixia Dai, Lin Li, Wenlu Liu, Fenghua Wang, Chuanqing Zhou

Author Affiliations +

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 1049469 (2018) https://doi.org/10.1117/12.2288989
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Determination of the precise location and degree of condition of the Choroidal neovascularization (CNV) lesion is essential for diagnosation Neovascular age-related macular degeneration (AMD) and evaluation the efficacy of treatment. Given the complimentary contrast mechanisms of Photoacoustic microscopy (PAM) and Optical coherence tomography (OCT), the combination of PAM and OCT imaging could potentially provide much sensitive and specific detection of CNV. In this paper, we validated the opportunity to evaluate the information of laser-induced CNV and presented the in vivo time-serial evaluation of the CNV by simultaneously using PAM and OCT techniques. In vivo PAM and OCT examination was performed after laser photocoagulation applied to the rat fundus at days 1, 3, 5, 7, 14. Time-serial results showed that CNV in rats increased to its maximum at day 7 and decreased at day 14. Evolution of CNV information was given in PAM images with a high contrast and details of high axial resolution OCT images were simultaneously given to show the hyperreflective reaction progress.

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Cuixia Dai, Lin Li, Wenlu Liu, Fenghua Wang, and Chuanqing Zhou "In vivo time-serial evaluation of laser-induced choroidal neovascularization in rats simultaneously using photoacoustic microscopy and optical coherence tomography", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 1049469 (19 February 2018); https://doi.org/10.1117/12.2288989

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KEYWORDS

Optical coherence tomography

In vivo imaging

Retina

Photoacoustic microscopy

Laser coagulation

Animal model studies

Pathogens

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