Optimization of light illumination for photoacoustic computed tomography of human infant brain

Sadreddin Mahmoodkalayeh; Xun Lu; Mohammad Ali Ansari; Hengguang Li; Mohammadreza Nasiriavanaki

doi:10.1117/12.2291592

26 February 2018 Optimization of light illumination for photoacoustic computed tomography of human infant brain

Sadreddin Mahmoodkalayeh, Xun Lu, Mohammad Ali Ansari, Hengguang Li, Mohammadreza Nasiriavanaki

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 104946U (2018) https://doi.org/10.1117/12.2291592
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Photoacoustic imaging (PAI) is an imaging modality for obtaining absorption coefficient at every location inside the tissue based on the detected photoacoustic signals. PA image reconstruction aims to determine the initial PA pressure everywhere inside the tissue. The pressure is proportional to both absorption coefficient and light fluence. Provided that fluence is homogenous, the reconstructed image will be an accurate mapping of the absorption coefficient of the tissue. Here we presented a method for obtaining uniform fluence inside the region of interest. We created a large dataset of fluence maps for different source locations, diameters and numerical apertures with Monte Carlo simulations, then used this dataset to solve an optimization problem for finding the source configuration which results in the best fluence distribution.

Citation Download Citation

Sadreddin Mahmoodkalayeh, Xun Lu, Mohammad Ali Ansari, Hengguang Li, and Mohammadreza Nasiriavanaki "Optimization of light illumination for photoacoustic computed tomography of human infant brain", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104946U (26 February 2018); https://doi.org/10.1117/12.2291592

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available