The interaction between the meningeal lymphatics and blood-brain barrier

O. Semyachkina-Glushkovskaya; A. Abdurashitov; A. Dubrovsky; A. Pavlov; N. Shushunova; G. Maslyakova; N. Navolokin; A. Bucharskaya; V. Tuchin; J. Kurths

doi:10.1117/12.2289406

19 February 2018 The interaction between the meningeal lymphatics and blood-brain barrier

O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Dubrovsky, A. Pavlov, N. Shushunova, G. Maslyakova, N. Navolokin, A. Bucharskaya, V. Tuchin, J. Kurths

Author Affiliations +

Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 104950J (2018) https://doi.org/10.1117/12.2289406
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Here we show the interaction between the meningeal lymphatic system and the blood-brain barrier (BBB) function. In normal state, the meningeal lymphatic vessels are invisible on optical coherent tomography (OCT), while during the opening of the BBB, meningeal lymphatic vessels are clearly visualized by OCT in the area of cerebral venous sinuses. These results give a significant impulse in the new application of OCT for the study of physiology of meningeal lymphatic system as well as sheds light on novel strategies in the prognosis of the opening of the BBB related with many central nervous system diseases, such as stroke, brain trauma, Alzheimers disease, etc.

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O. Semyachkina-Glushkovskaya, A. Abdurashitov, A. Dubrovsky, A. Pavlov, N. Shushunova, G. Maslyakova, N. Navolokin, A. Bucharskaya, V. Tuchin, and J. Kurths "The interaction between the meningeal lymphatics and blood-brain barrier", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 104950J (19 February 2018); https://doi.org/10.1117/12.2289406

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