19 February 2018 RGD peptide-targeted polyethylenimine-entrapped gold nanoparticles for targeted CT imaging of an orthotopic model of human hepatocellular carcinoma
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Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 104950O (2018) https://doi.org/10.1117/12.2285290
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
We report the synthesis and characterization of arginine-glycine-aspartic acid (RGD) peptide-targeted polyethylenimine (PEI)-entrapped gold nanoparticles (RGD-Au PENPs) for targeted CT imaging of hepatic carcinomas in situ. In this work, PEI sequentially modified with polyethylene glycol (PEG), and RGD linked-PEG was used as a nanoplatform to prepare AuNPs, followed by complete acetylation of PEI surface amines. We showed that the designed RGD-Au PENPs were colloidally stable and biocompatible in the given concentration range, and could be specifically taken up by αvβ3 integrin-overexpressing liver cancer cells in vitro. Furthermore, in vivo CT imaging results revealed that the particles displayed a great contrast enhancement of hepatic carcinomas region, and could target to hepatic carcinomas region in situ. With the proven biodistribution and histological examinations in vivo, the synthesized RGD-Au PENPs show a great formulation to be used as a contrast agent for targeted CT imaging of different αvβ3 integrin receptoroverexpressing tumors.
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Benqing Zhou, Meng Wang, Feifan Zhou, Jun Song, Junle Qu, Wei R. Chen, "RGD peptide-targeted polyethylenimine-entrapped gold nanoparticles for targeted CT imaging of an orthotopic model of human hepatocellular carcinoma", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 104950O (19 February 2018); doi: 10.1117/12.2285290; https://doi.org/10.1117/12.2285290
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