19 February 2018 The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy
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Proceedings Volume 10495, Biophotonics and Immune Responses XIII; 1049510 (2018) https://doi.org/10.1117/12.2291694
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
We extend our model of the antitumor immune response initiated by laser-immunotherapy treatment to more closely examine key steps in the immune response 1) tumor antigen acquisition by antigen-presenting dendritic cells (DCs) and 2) cytotoxic T cell (CTL) priming by lymphatic DCs. Specifically we explore the formation of DC-CTL complexes that lead to CTL priming. We find that the bias in the dissociation rate of the complex influences the outcome of treatment. In particular, a bias towards priming favors a rapid activated CTL response and the clearance of tumors.
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Sean M. Laverty, Sean M. Laverty, Bryan A. Dawkins, Bryan A. Dawkins, Wei R. Chen, Wei R. Chen, } "The role and mechanics of dendritic cells in tumor antigen acquisition and presentation following laser immunotherapy", Proc. SPIE 10495, Biophotonics and Immune Responses XIII, 1049510 (19 February 2018); doi: 10.1117/12.2291694; https://doi.org/10.1117/12.2291694
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