High-resolution optical polarimetric elastography for measuring the mechanical properties of tissue

Alexa W. Hudnut; Andrea M. Armani

doi:10.1117/12.2285443

19 February 2018 High-resolution optical polarimetric elastography for measuring the mechanical properties of tissue

Alexa W. Hudnut, Andrea M. Armani

Proceedings Volume 10496, Optical Elastography and Tissue Biomechanics V; 1049606 (2018) https://doi.org/10.1117/12.2285443
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Traditionally, chemical and molecular markers have been the predominate method in diagnostics. Recently, alternate methods of determining tissue and disease characteristics have been proposed based on testing the mechanical behavior of biomaterials. Existing methods for performing elastography measurements, such as atomic force microscopy, compression testing, and ultrasound elastography, require either extensive sample processing or have poor resolution. In the present work, we demonstrate an optical polarimetric elastography device to characterize the mechanical properties of salmon skeletal muscle. A fiber-coupled 1550nm laser paired with an optical polarizer is used to create a fiber optic sensing region. By measuring the change in polarization from the initial state to the final state within the fiber sensing region with a polarimeter, the loading-unloading curves can be determined for the biomaterial. The device is used to characterize the difference between samples with a range of collagen membranes. The loading-unloading curves are used to determine the change in polarization phase and energy loss of the samples at 10%, 20% and 30% strain. As expected, the energy loss is a better metric for measuring the mechanical properties of the tissues because it incorporates the entire loading-unloading curve rather than a single point. Using this metric, it is demonstrated the device can repeatedly differentiate between the different membrane configurations.

Conference Presentation

Citation Download Citation

Alexa W. Hudnut and Andrea M. Armani "High-resolution optical polarimetric elastography for measuring the mechanical properties of tissue", Proc. SPIE 10496, Optical Elastography and Tissue Biomechanics V, 1049606 (19 February 2018); https://doi.org/10.1117/12.2285443

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available