Brillouin light scattering spectroscopy for tissue engineering application

Dana Akilbekova; Talgat Yakupov; Vyacheslav Ogay; Bauyrzhan Umbayev; Vladislav V. Yakovlev; Zhandos N. Utegulov

doi:10.1117/12.2289923

19 February 2018 Brillouin light scattering spectroscopy for tissue engineering application

Dana Akilbekova, Talgat Yakupov, Vyacheslav Ogay, Bauyrzhan Umbayev, Vladislav V. Yakovlev, Zhandos N. Utegulov

Author Affiliations +

Proceedings Volume 10496, Optical Elastography and Tissue Biomechanics V; 104961I (2018) https://doi.org/10.1117/12.2289923
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Biomechanical properties of mammalian bones, such as strength, toughness and plasticity, are essential for understanding how microscopic scale mechanical features can link to macroscale bones’ strength and fracture resistance. We employ Brillouin light scattering (BLS) micro-spectroscopy for local assessment of elastic properties of bones under compression and the efficacy of the tissue engineering approach based on heparin-conjugated fibrin (HCF) hydrogels, bone morphogenic proteins (BMPs) and osteogenic stem cells in the regeneration of the bone tissues. BLS is noninvasive and label-free imaging modality for probing mechanical properties of hard tissues that can give information on structure-function properties of normal and pathological tissues. Results showed that HCF gels containing combination of all factors had the best effect with complete defect regeneration at week 9 and that the bones with fully consolidated fractures have higher values of elastic moduli compared to the bones with defects.

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Dana Akilbekova, Talgat Yakupov, Vyacheslav Ogay, Bauyrzhan Umbayev, Vladislav V. Yakovlev, and Zhandos N. Utegulov "Brillouin light scattering spectroscopy for tissue engineering application", Proc. SPIE 10496, Optical Elastography and Tissue Biomechanics V, 104961I (19 February 2018); https://doi.org/10.1117/12.2289923

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