20 February 2018 A novel small molecule mediate 18F-FDG excited fluorescence molecular imaging
Author Affiliations +
Fluorescence molecular imaging (FMI) has been widely used in many medical fields with small molecule indocyanine green (ICG). However, low signal-background ratio and limited specificity to tumor remain big challenges for FMI. In this study, a novel excitation strategy is proposed on the basis of clinical approved ICG and 18F-FDG. A series of in vitro experiments are designed to reveal the mechanism and results show obvious decreasing of ICG fluorescence intensity with the increasing distance to excitation source. Meanwhile, the ICG fluorescence intensity is proportional to the activity of radiopharmaceutical. Results from different respects illustrate the promising of this proposed excitation strategy.
Conference Presentation
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Zeyu Zhang, Zeyu Zhang, Hongbo Guo, Hongbo Guo, Zhenhua Hu, Zhenhua Hu, Jie Tian, Jie Tian, } "A novel small molecule mediate 18F-FDG excited fluorescence molecular imaging", Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 1049705 (20 February 2018); doi: 10.1117/12.2291300; https://doi.org/10.1117/12.2291300

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