20 February 2018 In vivo observation of transient photoreceptor movement correlated with oblique light stimulation
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Abstract
Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for high resolution assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its fast time course and sub-cellular signal magnitude. By developing a line-scanning and virtually structured detection based super-resolution ophthalmoscope, we report here in vivo observation of TRP in frog retina. In vivo characterization of TRP time course and magnitude were implemented by using variable light stimulus intensities.
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Yiming Lu, Changgeng Liu, Xincheng Yao, "In vivo observation of transient photoreceptor movement correlated with oblique light stimulation ", Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 104971M (20 February 2018); doi: 10.1117/12.2287262; https://doi.org/10.1117/12.2287262
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