20 February 2018 In vivo observation of transient photoreceptor movement correlated with oblique light stimulation
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Abstract
Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for high resolution assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its fast time course and sub-cellular signal magnitude. By developing a line-scanning and virtually structured detection based super-resolution ophthalmoscope, we report here in vivo observation of TRP in frog retina. In vivo characterization of TRP time course and magnitude were implemented by using variable light stimulus intensities.
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Yiming Lu, Yiming Lu, Changgeng Liu, Changgeng Liu, Xincheng Yao, Xincheng Yao, } "In vivo observation of transient photoreceptor movement correlated with oblique light stimulation ", Proc. SPIE 10497, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVI, 104971M (20 February 2018); doi: 10.1117/12.2287262; https://doi.org/10.1117/12.2287262
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