28 February 2018 Scatterer density sensitive tomography utilizing light and ultrasound
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Hybrid imaging modalities are becoming more popular since they utilize the benefit of both optical and ultrasound (US) imaging modalities. They use the contrast based on optical properties and negligible scattering of US waves to extend the depth of imaging. Ultrasound modulated optical tomography (UOT) and acoustic radiation force (ARF) with speckle pattern analysis, both use the idea of utilizing a focused US wave to spatially encode in information in the diffused light. We have previously shown that compared to UOT, ARF regime can result in a stronger signal and the mean irradiance change (MIC) signal can reflect the mechanical and thermal properties of the tissue non-invasively. In addition to the mechanical and thermal properties of the medium, the MIC signal is able to reveal information about the morphology of the medium. A tumor is formed by a group of cancer cells that are result of rounds of successive mutation. Cancer cell grow without control in abnormal shapes. In this study, we have modeled cells with their nuclei, assuming that the scattering events occur at the location of the nuclei of the cells. We have shown that, although the MIC signal is not sensitive to the size of the particle, it can detect the presence of the tumor base on the higher concentration of cells in a tumor.
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Ali Vakili, Ali Vakili, R. Glynn Holt, R. Glynn Holt, Charles A. DiMarzio, Charles A. DiMarzio, } "Scatterer density sensitive tomography utilizing light and ultrasound", Proc. SPIE 10499, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXV, 104990C (28 February 2018); doi: 10.1117/12.2290418; https://doi.org/10.1117/12.2290418


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