20 February 2018 Computational circular dichroism estimation for point-of-care diagnostics via vortex half-wave retarders
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Observing the circular dichroism (CD) caused by organic molecules in biological fluids can provide powerful indicators of patient health and provide diagnostic clues for treatment. Methods for this kind of analysis involve tabletop devices that weigh tens of kilograms with costs on the order of tens of thousands of dollars, making them prohibitive in point-of-care diagnostic applications. In an e ort to reduce the size, cost, and complexity of CD estimation systems for point-of-care diagnostics, we propose a novel method for CD estimation that leverages a vortex half-wave retarder in between two linear polarizers and a two-dimensional photodetector array to provide an overall complexity reduction in the system. This enables the measurement of polarization variations across multiple polarizations after they interact with a biological sample, simultaneously, without the need for mechanical actuation. We further discuss design considerations of this methodology in the context of practical applications to point-of-care diagnostics.
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Shahid A. Haider, Shahid A. Haider, Megan Y. Tran, Megan Y. Tran, Alexander Wong, Alexander Wong, } "Computational circular dichroism estimation for point-of-care diagnostics via vortex half-wave retarders", Proc. SPIE 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, 1050108 (20 February 2018); doi: 10.1117/12.2290619; https://doi.org/10.1117/12.2290619

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