20 February 2018 In-vivo quantitative measurement of tissue oxygen saturation of human webbing using a transmission type continuous-wave near-infrared spectroscopy
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Abstract
Near-infrared spectroscopy (NIRS) is a noninvasive method for monitoring tissue oxygen saturation (StO2). Many commercial NIRS devices are presently available. However, the precision of those devices is relatively poor because they are using the reflectance-model with which it is difficult to obtain the blood volume and other unchanged components of the tissue. Human webbing is a thin part of the hand and suitable to measure spectral transmittance. In this paper, we present a method for measuring StO2 of human webbing from a transmissive continuous-wave nearinfrared spectroscopy (CW-NIRS) data. The method is based on the modified Beer-Lambert law (MBL) and it consists of two steps. In the first step, we give a pressure to the upstream region of the measurement point to perturb the concentration of deoxy- and oxy-hemoglobin as remaining the other components and measure the spectral signals. From the measured data, spectral absorbance due to the components other than hemoglobin is calculated. In the second step, spectral measurement is performed at arbitrary time instance and the spectral absorbance obtained in the step 1 is subtracted from the measured absorbance. The tissue oxygen saturation (StO2) is estimated from the remained data. The method was evaluated on an arterial occlusion test (AOT) and a venous occlusion test (VOT). In the evaluation experiment, we confirmed that reasonable values of StO2 were obtained by the proposed method.
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Tuerxun Aizimu, Tuerxun Aizimu, Makoto Adachi, Makoto Adachi, Kazuya Nakano, Kazuya Nakano, Takashi Ohnishi, Takashi Ohnishi, Toshiya Nakaguchi, Toshiya Nakaguchi, Nozomi Takahashi, Nozomi Takahashi, Taka-aki Nakada, Taka-aki Nakada, Shigeto Oda, Shigeto Oda, Hideaki Haneishi , Hideaki Haneishi , } "In-vivo quantitative measurement of tissue oxygen saturation of human webbing using a transmission type continuous-wave near-infrared spectroscopy", Proc. SPIE 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, 105010P (20 February 2018); doi: 10.1117/12.2291186; https://doi.org/10.1117/12.2291186
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