Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump

Daisuke Sakota; Tatsuki Fujiwara; Katsuhiro Ohuchi; Katsuyuki Kuwana; Hiroyuki Yamazaki; Ryo Kosaka; Osamu Maruyama

doi:10.1117/12.2288149

20 February 2018 Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump

Daisuke Sakota, Tatsuki Fujiwara, Katsuhiro Ohuchi, Katsuyuki Kuwana, Hiroyuki Yamazaki, Ryo Kosaka, Osamu Maruyama

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Proceedings Volume 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics; 105011B (2018) https://doi.org/10.1117/12.2288149
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

We developed an optical detector of thrombus formed on the pivot bearing of an extracorporeal centrifugal blood pump (MERA HCF-MP23; Senko Medical Instrument Mfg. Co., Ltd., Tokyo, Japan) which is frequently used for long-term extracorporeal circulation support to bridge to an implantable artificial heart, which in turn is used for bridge to heart transplantation in Japan. In this study, we investigated the quantitative performance of the thrombus formation in acute animal experiments. A total of three experiments of extracorporeal left ventricular assist using Japanese specific pathogen-free pigs were conducted. The optical fibers were set in the pump driver unit. The incident light at nearinfrared wavelength aiming at the pivot bearing and the resulting scattered light were guided to respective fibers. The detected signal was analyzed to obtain thrombus formation level (TFL) calculated by a specially developed software. When the increase in TFL was confirmed, the pump was exchanged and the extracorporeal circulation was restarted. The number of pump exchanges were four times at each experiment so a total of twelve pumps were evaluated. 3-dimentional data surrounding the pivot bearing and the adhered thrombus was captured by a 3-dimantional surface measurement system to calculate the thrombus surface area (TSA) formed on the pivot bearing. As a result, the correlation coefficient between TFL and TSA was 0.878. The accuracy of TSA estimated by the optical detector was 3.6±2.3 mm². This was small enough to not have the pump exchanged in clinical judgement. The developed detector would be useful for optimal anti-coagulation management.

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Daisuke Sakota, Tatsuki Fujiwara, Katsuhiro Ohuchi, Katsuyuki Kuwana, Hiroyuki Yamazaki, Ryo Kosaka, and Osamu Maruyama "Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump", Proc. SPIE 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics, 105011B (20 February 2018); https://doi.org/10.1117/12.2288149

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KEYWORDS

Blood

Sensors

Light scattering

Optical fibers

Signal detection

Detector development

Software development

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