20 February 2018 Two dimensional microcirculation mapping with real time spatial frequency domain imaging
Author Affiliations +
We present a spatial frequency domain imaging (SFDI) study of local hemodynamics in the human finger cuticle of healthy volunteers performing paced breathing and the forearm of healthy young adults performing normal breathing with our recently developed Real Time Single Snapshot Multiple Frequency Demodulation – Spatial Frequency Domain Imaging (SSMD-SFDI) system. A two-layer model was used to map the concentrations of deoxy-, oxy-hemoglobin, melanin, epidermal thickness and scattering properties at the subsurface of the forearm and the finger cuticle. The oscillations of the concentrations of deoxy- and oxy-hemoglobin at the subsurface of the finger cuticle and forearm induced by paced breathing and normal breathing, respectively, were found to be close to out-of-phase, attributed to the dominance of the blood flow modulation by paced breathing or heartbeat. Our results suggest that the real time SFDI platform may serve as one effective imaging modality for microcirculation monitoring.
Conference Presentation
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Yang Zheng, Yang Zheng, Xinlin Chen, Xinlin Chen, Weihao Lin, Weihao Lin, Zili Cao, Zili Cao, Xiuwei Zhu, Xiuwei Zhu, Bixin Zeng, Bixin Zeng, M. Xu, M. Xu, } "Two dimensional microcirculation mapping with real time spatial frequency domain imaging", Proc. SPIE 10505, High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management, 105050X (20 February 2018); doi: 10.1117/12.2287317; https://doi.org/10.1117/12.2287317

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