20 February 2018 Highly-sensitive and large-dynamic diffuse optical tomography system for breast tumor detection
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Diffuse optical tomography (DOT) as a new functional imaging has important clinical applications in many aspects such as benign and malignant breast tumor detection, tumor staging and so on. For quantitative detection of breast tumor, a three-wavelength continuous-wave DOT prototype system combined the ultra-high sensitivity of the photon-counting detection and the measurement parallelism of the lock-in technique was developed to provide high temporal resolution, high sensitivity, large dynamic detection range and signal-to-noise ratio. Additionally, a CT-analogous scanning mode was proposed to cost-effectively increase the detection data. To evaluate the feasibility of the system, a series of assessments were conducted. The results demonstrate that the system can obtain high linearity, stability and negligible inter-wavelength crosstalk. The preliminary phantom experiments show the absorption coefficient is able to be successfully reconstructed, indicating that the system is one of the ideal platforms for optical breast tumor detection.
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Wenwen Du, Wenwen Du, Limin Zhang, Limin Zhang, Guoyan Yin, Guoyan Yin, Yanqi Zhang, Yanqi Zhang, Huijuan Zhao, Huijuan Zhao, Feng Gao, Feng Gao, } "Highly-sensitive and large-dynamic diffuse optical tomography system for breast tumor detection", Proc. SPIE 10505, High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management, 1050515 (20 February 2018); doi: 10.1117/12.2288725; https://doi.org/10.1117/12.2288725

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