Investigating the stability of DNA-coated gold nanoparticles

Maria-Eleni Kyriazi; Antonios G. Kanaras

doi:10.1117/12.2285833

23 February 2018 Investigating the stability of DNA-coated gold nanoparticles

Maria-Eleni Kyriazi, Antonios G. Kanaras

Proceedings Volume 10507, Colloidal Nanoparticles for Biomedical Applications XIII; 105070A (2018) https://doi.org/10.1117/12.2285833
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

In this paper we investigate how the density of oligonucleotides around spherical 15 nm gold nanoparticles (AuNPs) influences their stability against degradation by DNase I. We show that a significant decrease in the number of oligonucleotides attached to the AuNP surface is directly correlated with an increase in the DNA degradation by DNase I. Our experimental observations suggest that a close packing of oligonucleotides into a 3d arrangement at the surface of AuNPs endows the probes with the necessary stability required for their use in intracellular applications.

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Citation Download Citation

Maria-Eleni Kyriazi and Antonios G. Kanaras "Investigating the stability of DNA-coated gold nanoparticles ", Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 105070A (23 February 2018); https://doi.org/10.1117/12.2285833

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