23 February 2018 Investigating the stability of DNA-coated gold nanoparticles
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Abstract
In this paper we investigate how the density of oligonucleotides around spherical 15 nm gold nanoparticles (AuNPs) influences their stability against degradation by DNase I. We show that a significant decrease in the number of oligonucleotides attached to the AuNP surface is directly correlated with an increase in the DNA degradation by DNase I. Our experimental observations suggest that a close packing of oligonucleotides into a 3d arrangement at the surface of AuNPs endows the probes with the necessary stability required for their use in intracellular applications.
Conference Presentation
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Maria-Eleni Kyriazi, Antonios G. Kanaras, "Investigating the stability of DNA-coated gold nanoparticles ", Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 105070A (23 February 2018); doi: 10.1117/12.2285833; https://doi.org/10.1117/12.2285833
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