23 February 2018 Investigating the stability of DNA-coated gold nanoparticles
Author Affiliations +
Abstract
In this paper we investigate how the density of oligonucleotides around spherical 15 nm gold nanoparticles (AuNPs) influences their stability against degradation by DNase I. We show that a significant decrease in the number of oligonucleotides attached to the AuNP surface is directly correlated with an increase in the DNA degradation by DNase I. Our experimental observations suggest that a close packing of oligonucleotides into a 3d arrangement at the surface of AuNPs endows the probes with the necessary stability required for their use in intracellular applications.
Conference Presentation
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Maria-Eleni Kyriazi, Maria-Eleni Kyriazi, Antonios G. Kanaras, Antonios G. Kanaras, } "Investigating the stability of DNA-coated gold nanoparticles ", Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 105070A (23 February 2018); doi: 10.1117/12.2285833; https://doi.org/10.1117/12.2285833
PROCEEDINGS
10 PAGES + PRESENTATION

SHARE
RELATED CONTENT

Size dependence of gold nanorod stability the need for...
Proceedings of SPIE (March 11 2015)
Functionalized nanoparticles and applications
Proceedings of SPIE (February 21 2017)
Nanoparticles in sensing
Proceedings of SPIE (April 21 2016)
Functional nanoparticles in cells
Proceedings of SPIE (February 01 2012)
Gold nanoparticles in biomedical applications
Proceedings of SPIE (February 11 2011)

Back to Top