23 February 2018 Cancer nanomedicine: gold nanoparticle mediated combined cancer therapy
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Recent developments in nanotechnology has provided new tools for cancer therapy and diagnosis. Among other nanomaterial systems, gold nanoparticles are being used as radiation dose enhancers and anticancer drug carriers in cancer therapy. Fate of gold nanoparticles within biological tissues can be probed using techniques such as TEM (transmission electron microscopy) and SEM (Scanning Electron Microscopy) due to their high electron density. We have shown for the first time that cancer drug loaded gold nanoparticles can reach the nucleus (or the brain) of cancer cells enhancing the therapeutic effect dramatically. Nucleus of the cancer cells are the most desirable target in cancer therapy. In chemotherapy, smart delivery of highly toxic anticancer drugs through packaging using nanoparticles will reduce the side effects and improve the quality and care of cancer patients. In radiation therapy, use of gold nanoparticles as radiation dose enhancer is very promising due to enhanced localized dose within the cancer tissue. Recent advancement in nanomaterial characterization techniques will facilitate mapping of nanomaterial distribution within biological specimens to correlate the radiobiological effects due to treatment. Hence, gold nanoparticle mediated combined chemoradiation would provide promising tools to achieve personalized and tailored cancer treatments in the near future.
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C. Yang, C. Yang, Kyle Bromma, Kyle Bromma, B. D. Chithrani, B. D. Chithrani, "Cancer nanomedicine: gold nanoparticle mediated combined cancer therapy", Proc. SPIE 10507, Colloidal Nanoparticles for Biomedical Applications XIII, 105070X (23 February 2018); doi: 10.1117/12.2295461; https://doi.org/10.1117/12.2295461

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