Clinically translatable nanotheranostic platforms for peripheral nerve regeneration: design with outcome in mind

Jelena M. Janjic; Vijay S. Gorantla

doi:10.1117/12.2289288

20 February 2018 Clinically translatable nanotheranostic platforms for peripheral nerve regeneration: design with outcome in mind

Jelena M. Janjic, Vijay S. Gorantla

Author Affiliations +

Proceedings Volume 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X; 1050803 (2018) https://doi.org/10.1117/12.2289288
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Neuroinflammation is a dynamic immune phenomenon that changes in severity with time after neurotrauma and has a profound impact on neuroregeneration, tissue healing and neuropathic pain, which is a common consequence of peripheral nerve injury (PNI). Macrophages are key cellular mediators of neuroinflammation. Macrophage-targeted nanotherapies, such as complex (perfluorocarbon/hydrocarbon) multimodal nanoemulsions (NEs) provide highly specific imaging signatures of neuroinflammation and hence indirect surrogate metrics of regeneration. We present a novel strategy where these NEs incorporating multiple imaging modalities and biosensors are delivered locally to directly target key cellular players of neuroregeneration. Two representative formulations of a nanotheranostic platform for local delivery of cell targeted NEs are presented: 1) A dual (macrophage and neuronal) targeted nanoparticle laden hydrogel for synergistic modulation of neuroinflammation and analgesia following PNI; and 2) neurotherapeutic loaded nanoparticles with extended release profile for sustained support of neuroregeneration. Each platform is capable of dual imaging payloads (NIRF, MRI and/or PET) and/or cell specific targeting moieties for controlled drug release. In vitro and pilot in vivo results will be presented. Theranostic nanosystem based platforms offer a unique opportunity to sequentially monitor cellular and molecular events at the site of neuronal injury, enabling dynamic, in-vivo mechanistic insights rather than static, ex-vivo histopathologic evaluation. Given their targeted capabilities, these platforms can help achieve personalized treatments that are customized and optimized for patients with PNI.

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Jelena M. Janjic and Vijay S. Gorantla "Clinically translatable nanotheranostic platforms for peripheral nerve regeneration: design with outcome in mind", Proc. SPIE 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X, 1050803 (20 February 2018); https://doi.org/10.1117/12.2289288

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KEYWORDS

Injuries

Nerve

Tissues

In vitro testing

In vivo imaging

Nerve regeneration

Modulation

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