16 February 2018 Femtosecond laser induced periodic nanostructures formation on medical polymer plate surface for control of cell spreading
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Abstract
Poly-methyl methacrylate (PMMA) has been widely used as biomaterial. In order to add a new function to PMMA, we developed a method to form periodic nanostructures on PMMA surface by femtosecond laser irradiation with a wavelength of 800 nm. Since PMMA had a low absorbance of light in the near-infrared wavelength region, it was difficult to form the structures by femtosecond laser irradiation on PMMA surface. We proposed a method that the femtosecond laser was focused on a titanium (Ti) plate surface through a polymer plate. As a result, the depth of the periodic nanostructures was about 70 nm, and the period of it was about 410 nm. A cell cultivation test was carried out on PMMA plate with and without periodic nanostructures. Consequently, although cells (MG-63) on the non-irradiated PMMA plate were spread in a random direction, cell spreading on the PMMA plate with periodic nanostructures occurs along the grooves.
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K. Takenaka, K. Takenaka, M. Tsukamoto, M. Tsukamoto, T. Ooga, T. Ooga, Y. Sato, Y. Sato, K. Murai, K. Murai, S. Asai, S. Asai, } "Femtosecond laser induced periodic nanostructures formation on medical polymer plate surface for control of cell spreading", Proc. SPIE 10519, Laser Applications in Microelectronic and Optoelectronic Manufacturing (LAMOM) XXIII, 105191A (16 February 2018); doi: 10.1117/12.2290224; https://doi.org/10.1117/12.2290224
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