19 February 2018 Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel
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Abstract
Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.
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T. Umemoto, T. Umemoto, M. Terakawa, M. Terakawa, } "Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel", Proc. SPIE 10522, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII, 1052203 (19 February 2018); doi: 10.1117/12.2287651; https://doi.org/10.1117/12.2287651
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