Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel

T. Umemoto; M. Terakawa

doi:10.1117/12.2287651

19 February 2018 Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel

T. Umemoto, M. Terakawa

Author Affiliations +

Proceedings Volume 10522, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII; 1052203 (2018) https://doi.org/10.1117/12.2287651
Event: SPIE LASE, 2018, San Francisco, California, United States

Abstract

Stimuli-responsible controlled release of growth factors from a tissue scaffold has gained significant interest for efficient tissue engineering. Laser-triggered methods for the molecular release have the advantage of spatial and temporal controllability. In this study, we demonstrate laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel for the aim of efficient tissue engineering. The microcapsules, which fluorescent molecules were encapsulated, were fabricated using a dual-coaxial nozzle system. The microcapsule suspension was mixed with gelatin solution, followed by cross-linking to fabricate a gelatin hydrogel. Femtosecond laser pulses were focused onto the hydrogel to release fluorescent molecules from the microcapsules in the gelatin hydrogel.

Citation Download Citation

T. Umemoto and M. Terakawa "Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in gelatin hydrogel", Proc. SPIE 10522, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVIII, 1052203 (19 February 2018); https://doi.org/10.1117/12.2287651

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