23 February 2018 Terahertz spectroscopy using an injection-seeded terahertz parametric generator for quantitative analysis and inspection of over-the-counter medicine tablets
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Abstract
The pharmaceutical industry requires a simple nondestructive quantitative inspection technique that does not change the characteristic properties of the target of inspection. Terahertz (THz) spectroscopy has potential as a nondestructive inspection technique because of the high transmittance of inspected materials and the absorption peaks related to some active pharmaceutical ingredients (APIs) in THz frequency regions. We have developed a compact terahertz spectroscopy system that uses an injection-seeded terahertz parametric generator (is-TPG) as a THz light source for the inspection and quantitative analysis of pharmaceutical tablets. Using this system, acetylsalicylic acid, acetaminophen, tranexamic acid, loxoprofen sodium, and caffeine included in over-the-counter (OTC) medicine tablets were identified as APIs by their specific absorption peaks. We also conducted a quantitative analysis of acetaminophen in one of the medicines by performing multivariate analyses. The root-mean-squared error of cross-validation (RMSECV) was 0.297 wt%. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.990 wt% and 3.00 wt%, respectively. These results indicate that this is-TPG system could be applied as an inspection and quantitative analysis technique for OTC medicine tablets.
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M. Mohara, K. Shimura, K. Aiko, K. Kawase, "Terahertz spectroscopy using an injection-seeded terahertz parametric generator for quantitative analysis and inspection of over-the-counter medicine tablets", Proc. SPIE 10531, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XI, 1053121 (23 February 2018); doi: 10.1117/12.2288029; https://doi.org/10.1117/12.2288029
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