Translator Disclaimer
14 March 2018 MEMS based multi-spectral dual-axis confocal microendoscope for clinical applications (Conference Presentation)
Author Affiliations +
Proceedings Volume 10545, MOEMS and Miniaturized Systems XVII; 105450N (2018) https://doi.org/10.1117/12.2292262
Event: SPIE OPTO, 2018, San Francisco, California, United States
Abstract
MEMS based microendoscopes have become important imaging tools for early cancer diagnosis and precise tumor resection. Due to various technical challenges, few microendoscopes have been translated to clinics or applied to human patients. Through synergistic collaborations, we have developed novel MEMS scanner enabled microendoscopic multispectral (640nm to 780nm) three- dimensional dual-axis confocal fluorescent imaging system for translational applications, including early cancer detection and staging on colorectal cancer, molecular imaging guided surgical navigation on head and neck cancer. Based on dual-axis confocal microscopic architecture, we have miniaturized the imaging system with compact form-factor by integrating micro-optics and a patterned gold coated MEMS scanners, which have been custom-made and mass-produced in the nanofabrication foundry. The metal coating of the scanning mirror provide over 80% high reflectivity over near infra-red range. Both axes of the MEMS scanner could perform large tilting angle (> 6 degree mechanical scan angle) at DC and resonant mode. By advanced computational imaging approach, we have achieved real-time cross-sectional imaging in either raster or lissajous pattern scanning with fast frame rate (> 10 Hz) with large field-of-view (> 600 microns). Advanced real-time mosaicing algorithm has been developed to achieve broader view in millimeter scale. By utilizing molecular contrast probes conjugated with fluorescence dye, we have successfully demonstrated multi-spectral ex-vivo and in-vivo imaging on small animal tumor models and human tissue specimens, aimed for both early cancer detection and molecular imaging guided surgical navigation.
Conference Presentation
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Zhen Qiu, Nathan Loewke, Wibool Piyawattanametha, Il-woong Jung, Tarn Teraphongphom, Robert Ertsey, Frank Schonig, Stephan Rogalla, Shai Friedland, Michael Mandella, Daniel Lopez, Eben Rosenthal, and Christopher Contag "MEMS based multi-spectral dual-axis confocal microendoscope for clinical applications (Conference Presentation)", Proc. SPIE 10545, MOEMS and Miniaturized Systems XVII, 105450N (14 March 2018); https://doi.org/10.1117/12.2292262
PROCEEDINGS
PRESENTATION ONLY


SHARE
Advertisement
Advertisement
RELATED CONTENT

Towards 3D printed confocal endoscopy
Proceedings of SPIE (September 28 2016)
Long term imaging of living brain cancer cells
Proceedings of SPIE (February 12 2018)
Prediction of tumor volumes using an exponential model
Proceedings of SPIE (March 30 2007)
Multi-modality molecular imaging for gastric cancer research
Proceedings of SPIE (November 29 2011)
NIR optical probes targeting glucose transporters
Proceedings of SPIE (June 14 2004)

Back to Top