22 February 2018 Integration and biocompatible packaging of multi-modal endoscopic imagers using 3D glass micro structuring
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Proceedings Volume 10545, MOEMS and Miniaturized Systems XVII; 105450Q (2018) https://doi.org/10.1117/12.2289480
Event: SPIE OPTO, 2018, San Francisco, California, United States
Multi-modal endomicroscopy is one of the most promising means to enable optical biopsy methods to attain the specificity and selectivity of conventional biopsy. However, the development of the complex opto-mechanical systems needs very high assembly tolerances, and robust, biocompatible and ultra-slim packaging solutions. Therefore, the prototyping and low-volume manufacturing of multi-modal endomicroscopes are often costly and time intensive processes.

We present the opto-mechanical design of a novel endomicroscope combining wide-field microscopy and 3D OCT, and demonstrate the advantages of 3D glass micro structuring based assembly and packaging in terms of optical performance and device miniaturization. Using ray-tracing based Monte Carlo simulations, we demonstrate that this precision leads to a significantly better optical performance compared to that offered by rival 3D machining techniques, such as the state-of-the-art 3D polymer printers and conventional micromachining based solutions.
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Simon Kretschmer, Jan Jäger, Sergio Vilches, Çaglar Ataman, Hans Zappe, "Integration and biocompatible packaging of multi-modal endoscopic imagers using 3D glass micro structuring", Proc. SPIE 10545, MOEMS and Miniaturized Systems XVII, 105450Q (22 February 2018); doi: 10.1117/12.2289480; https://doi.org/10.1117/12.2289480

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