17 November 2017 Acute effect of Vagus nerve stimulation parameters on cardiac chronotropic, inotropic, and dromotropic responses
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Proceedings Volume 10572, 13th International Conference on Medical Information Processing and Analysis; 105721C (2017) https://doi.org/10.1117/12.2286760
Event: 13th International Symposium on Medical Information Processing and Analysis, 2017, San Andres Island, Colombia
Abstract
Vagus nerve stimulation (VNS) is an established therapy for drug-resistant epilepsy and depression, and is considered as a potential therapy for other pathologies, including Heart Failure (HF) or inflammatory diseases. In the case of HF, several experimental studies on animals have shown an improvement in the cardiac function and a reverse remodeling of the cardiac cavity when VNS is applied. However, recent clinical trials have not been able to reproduce the same response in humans. One of the hypothesis to explain this lack of response is related to the way in which stimulation parameters are defined. The combined effect of VNS parameters is still poorly-known, especially in the case of VNS synchronously delivered with cardiac activity. In this paper, we propose a methodology to analyze the acute cardiovascular effects of VNS parameters individually, as well as their interactive effects. A Latin hypercube sampling method was applied to design a uniform experimental plan. Data gathered from this experimental plan was used to produce a Gaussian process regression (GPR) model in order to estimate unobserved VNS sequences. Finally, a Morris screening sensitivity analysis method was applied to each obtained GPR model. Results highlight dominant effects of pulse current, pulse width and number of pulses over frequency and delay and, more importantly, the degree of interactions between these parameters on the most important acute cardiovascular responses. In particular, high interacting effects between current and pulse width were found. Similar sensitivity profiles were observed for chronotropic, dromotropic and inotropic effects. These findings are of primary importance for the future development of closed-loop, personalized neuromodulator technologies.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
David Ojeda, David Ojeda, Virginie Le Rolle, Virginie Le Rolle, Hector M. Romero-Ugalde, Hector M. Romero-Ugalde, Clément Gallet, Clément Gallet, Jean-Luc Bonnet, Jean-Luc Bonnet, Christine Henry, Christine Henry, Alain Bel, Alain Bel, Philippe Mabo, Philippe Mabo, Guy Carrault, Guy Carrault, Alfredo I. Hernández, Alfredo I. Hernández, } "Acute effect of Vagus nerve stimulation parameters on cardiac chronotropic, inotropic, and dromotropic responses", Proc. SPIE 10572, 13th International Conference on Medical Information Processing and Analysis, 105721C (17 November 2017); doi: 10.1117/12.2286760; https://doi.org/10.1117/12.2286760
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