17 November 2017 A quantitative reconstruction software suite for SPECT imaging
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Proceedings Volume 10572, 13th International Conference on Medical Information Processing and Analysis; 105721K (2017) https://doi.org/10.1117/12.2284704
Event: 13th International Symposium on Medical Information Processing and Analysis, 2017, San Andres Island, Colombia
Abstract
Quantitative Single Photon Emission Tomography (SPECT) imaging allows for measurement of activity concentrations of a given radiotracer in vivo. Although SPECT has usually been perceived as non-quantitative by the medical community, the introduction of accurate CT based attenuation correction and scatter correction from hybrid SPECT/CT scanners has enabled SPECT systems to be as quantitative as Positron Emission Tomography (PET) systems. We implemented a software suite to reconstruct quantitative SPECT images from hybrid or dedicated SPECT systems with a separate CT scanner. Attenuation, scatter and collimator response corrections were included in an Ordered Subset Expectation Maximization (OSEM) algorithm. A novel scatter fraction estimation technique was introduced. The SPECT/CT system was calibrated with a cylindrical phantom and quantitative accuracy was assessed with an anthropomorphic phantom and a NEMA/IEC image quality phantom. Accurate activity measurements were achieved at an organ level. This software suite helps increasing quantitative accuracy of SPECT scanners.
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Mauro Namías, Robert Jeraj, "A quantitative reconstruction software suite for SPECT imaging", Proc. SPIE 10572, 13th International Conference on Medical Information Processing and Analysis, 105721K (17 November 2017); doi: 10.1117/12.2284704; https://doi.org/10.1117/12.2284704
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