Design, construction, and initial results of a prototype multi-contrast x-ray breast imaging system

Ke Li; Ran Zhang; John Garrett; Yongshuai Ge; Xu Ji; Guang-Hong Chen

doi:10.1117/12.2293921

9 March 2018 Design, construction, and initial results of a prototype multi-contrast x-ray breast imaging system

Ke Li, Ran Zhang, John Garrett, Yongshuai Ge, Xu Ji, Guang-Hong Chen

Proceedings Volume 10573, Medical Imaging 2018: Physics of Medical Imaging; 105730W (2018) https://doi.org/10.1117/12.2293921
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

By integrating a grating-based interferometer with a clinical full field digital mammography (FFDM) system, a prototype multi-contrast (absorption, phase, and dark field) x-ray breast imaging system was developed in this work. Unlike previous benchtop-based multi-contrast x-ray imaging systems that usually have relatively long source-to-detector distance and vibration isolators or dampers for the interferometer, the FFDM hardware platform is subject to mechanical vibration and the constraint of compact system geometry. Current grating fabrication technology also imposes additional constraints on the design of the grating interferometer. Based on these technical constraints and the x-ray beam properties of the FFDM system, three gratings were designed and integrated with the FFDM system. When installing the gratings, no additional vibration damping device was used in order to test the robustness of multi-contrast imaging system against mechanical vibration. The measured visibility of the diffraction fringes was 23±3%, and two images acquired 60 minutes apart demonstrated good system reproducibility with no visible signal drift. Preliminary results generated from the prototype system demonstrate the multi-contrast imaging capability of the system. The three contrast mechanisms provide mutually complementary information of the phantom object. This prototype system provides a much needed platform for evaluating the true clinical utility of the multi-contrast x-ray imaging method for the diagnosis of breast cancer.

Conference Presentation

Citation Download Citation

Ke Li, Ran Zhang, John Garrett, Yongshuai Ge, Xu Ji, and Guang-Hong Chen "Design, construction, and initial results of a prototype multi-contrast x-ray breast imaging system", Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105730W (9 March 2018); https://doi.org/10.1117/12.2293921

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available