9 March 2018 Monochromatic breast CT: absorption and phase-retrieved images
Author Affiliations +
A program devoted to perform the first in-vivo monochromatic breast computed tomography (BCT) is ongoing at the Elettra Synchrotron Facility. Since the synchrotron radiation provides high energy resolution and spatial coherence, phase-contrast (PhC) imaging techniques can be used. The latest high resolution BCT acquisitions of breast specimens, obtained with the propagation-based PhC approach, are herein presented as part of a wider framework, devoted to the optimization of acquisition and reconstruction parameters towards the clinical exam. Images are acquired with a state-of-the-art dead-time-free single-photon-counting CdTe detector with a 60 µm pixel size. The samples are imaged at 32 and 38 keV in continuous rotating mode, delivering 5-20 mGy of mean glandular dose (MGD). Contrast-to-noise ratio (CNR) and spatial resolution performances are evaluated for both absorption and phase-retrieved images considering tumor/adipose tissue interfaces. We discuss two different phase-retrieval approaches, showing that a remarkable CNR increase (from 0.5 to 3.6) can be obtained without a significant loss in spatial resolution. It is shown that, even if the non-phase-retrieved image has a poorer CNR, it is useful for evaluating the spiculation of a microcalcification: in this context, absorption and phase-retrieved images have to be regarded as complementary information. Furthermore, the first full volume acquisition of a mastectomy, with a 9 cm diameter and 3 cm height, is reported. This investigation on surgical specimens indicates that monochromatic BCT with synchrotron radiation in terms of CNR, spatial resolution, scan duration and scan volume is feasible.
Conference Presentation
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Luca Brombal, Luca Brombal, Bruno Golosio, Bruno Golosio, Fulvia Arfelli, Fulvia Arfelli, Deborah Bonazza, Deborah Bonazza, Adriano Contillo, Adriano Contillo, Pasquale Delogu, Pasquale Delogu, Sandro Donato, Sandro Donato, Giovanni Mettivier, Giovanni Mettivier, Piernicola Oliva, Piernicola Oliva, Luigi Rigon, Luigi Rigon, Angelo Taibi, Angelo Taibi, Giuliana Tromba, Giuliana Tromba, Fabrizio Zanconati, Fabrizio Zanconati, Renata Longo, Renata Longo, } "Monochromatic breast CT: absorption and phase-retrieved images", Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 1057320 (9 March 2018); doi: 10.1117/12.2293088; https://doi.org/10.1117/12.2293088

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