9 March 2018 Projection tomography in the NIR-IIa window: challenges, advantages, and comparison with classical optical approach
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Abstract
Optical Projection Tomography (OPT) techniques are limited by the nature of light interaction with tissues. Some of these limitations arise from the scattering phenomena or the weak transparency of the samples, restricting the depth of penetration and the differentiation of structures due to image blurriness. Recent advances in detection technologies enable the use of new promising light spectrum imaging windows such as the Near-Infrared (NIR) II-a, which comprises wavelengths within the range between 1300 to 1400 nm. Light in this frequency band has interesting properties that could increase the depth of penetration, reduce the auto fluorescence and the scattering.

In this work we aim to explore the possibilities of this wavelengths and compare them with imaging in shorter wavelengths. At first, we have examined its optical properties in detail, finding which band of the spectrum works best for tissue imaging. Afterwards we built an OPT setup using two lasers with wavelengths from different windows to analyze the benefits of the IIa near infrared experimentally. Finally, we discuss the results and we propose ways to exploit all the advantages that the use of these wavelengths can bring into the state-of-the-art optical imaging techniques.
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A. Marcos-Vidal, D. Ancora, G. Zacharakis, J. J. Vaquero, J. Ripoll, "Projection tomography in the NIR-IIa window: challenges, advantages, and comparison with classical optical approach", Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105732F (9 March 2018); doi: 10.1117/12.2293708; https://doi.org/10.1117/12.2293708
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