9 March 2018 Anatomical DCE-MRI phantoms generated from glioma patient data
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Abstract
Several digital reference objects (DROs) for DCE-MRI have been created to test the accuracy of pharmacokinetic modeling software under a variety of different noise conditions. However, there are few DROs that mimic the anatomical distribution of voxels found in real data, and similarly few DROs that are based on both malignant and normal tissue. We propose a series of DROs for modeling Ktrans and Ve derived from a publically-available RIDER DCEMRI dataset of 19 patients with gliomas. For each patient’s DCE-MRI data, we generate Ktrans and Ve parameter maps using an algorithm validated on the QIBA Tofts model phantoms. These parameter maps are denoised, and then used to generate noiseless time-intensity curves for each of the original voxels. This is accomplished by reversing the Tofts model to generate concentration-times curves from Ktrans and Ve inputs, and subsequently converting those curves into intensity values by normalizing to each patient’s average pre-bolus image intensity. The result is a noiseless DRO in the shape of the original patient data with known ground-truth Ktrans and Ve values. We make this dataset publically available for download for all 19 patients of the original RIDER dataset.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrew Beers, Andrew Beers, Ken Chang, Ken Chang, James Brown, James Brown, Xia Zhu, Xia Zhu, Dipanjan Sengupta, Dipanjan Sengupta, Theodore L. Willke, Theodore L. Willke, Elizabeth Gerstner, Elizabeth Gerstner, Bruce Rosen, Bruce Rosen, Jayashree Kalpathy-Cramer, Jayashree Kalpathy-Cramer, } "Anatomical DCE-MRI phantoms generated from glioma patient data", Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105732V (9 March 2018); doi: 10.1117/12.2294961; https://doi.org/10.1117/12.2294961
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