27 February 2018 Improving performance of breast cancer risk prediction using a new CAD-based region segmentation scheme
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Abstract
Objective of this study is to develop and test a new computer-aided detection (CAD) scheme with improved region of interest (ROI) segmentation combined with an image feature extraction framework to improve performance in predicting short-term breast cancer risk. A dataset involving 570 sets of "prior" negative mammography screening cases was retrospectively assembled. In the next sequential "current" screening, 285 cases were positive and 285 cases remained negative. A CAD scheme was applied to all 570 "prior" negative images to stratify cases into the high and low risk case group of having cancer detected in the "current" screening. First, a new ROI segmentation algorithm was used to automatically remove useless area of mammograms. Second, from the matched bilateral craniocaudal view images, a set of 43 image features related to frequency characteristics of ROIs were initially computed from the discrete cosine transform and spatial domain of the images. Third, a support vector machine model based machine learning classifier was used to optimally classify the selected optimal image features to build a CAD-based risk prediction model. The classifier was trained using a leave-one-case-out based cross-validation method. Applying this improved CAD scheme to the testing dataset, an area under ROC curve, AUC = 0.70±0.04, which was significantly higher than using the extracting features directly from the dataset without the improved ROI segmentation step (AUC = 0.63±0.04). This study demonstrated that the proposed approach could improve accuracy on predicting short-term breast cancer risk, which may play an important role in helping eventually establish an optimal personalized breast cancer paradigm.
Conference Presentation
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Morteza Heidari, Morteza Heidari, Abolfazl Zargari Khuzani, Abolfazl Zargari Khuzani, Gopichandh Danala, Gopichandh Danala, Yuchen Qiu , Yuchen Qiu , Bin Zheng, Bin Zheng, } "Improving performance of breast cancer risk prediction using a new CAD-based region segmentation scheme", Proc. SPIE 10575, Medical Imaging 2018: Computer-Aided Diagnosis, 105750P (27 February 2018); doi: 10.1117/12.2293361; https://doi.org/10.1117/12.2293361
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