7 March 2018 Reducing the number of reconstructions needed for estimating channelized observer performance
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Abstract
A challenge for task-based optimization is the time required for each reconstructed image in applications where reconstructions are time consuming. Our goal is to reduce the number of reconstructions needed to estimate the area under the receiver operating characteristic curve (AUC) of the infinitely-trained optimal channelized linear observer. We explore the use of classifiers which either do not invert the channel covariance matrix or do feature selection. We also study the assumption that multiple low contrast signals in the same image of a non-linear reconstruction do not significantly change the estimate of the AUC. We compared the AUC of several classifiers (Hotelling, logistic regression, logistic regression using Firth bias reduction and the least absolute shrinkage and selection operator (LASSO)) with a small number of observations both for normal simulated data and images from a total variation reconstruction in magnetic resonance imaging (MRI). We used 10 Laguerre-Gauss channels and the Mann-Whitney estimator for AUC. For this data, our results show that at small sample sizes feature selection using the LASSO technique can decrease bias of the AUC estimation with increased variance and that for large sample sizes the difference between these classifiers is small. We also compared the use of multiple signals in a single reconstructed image to reduce the number of reconstructions in a total variation reconstruction for accelerated imaging in MRI. We found that AUC estimation using multiple low contrast signals in the same image resulted in similar AUC estimates as doing a single reconstruction per signal leading to a 13x reduction in the number of reconstructions needed.
Conference Presentation
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Angel R. Pineda, Hope Miedema, Melissa Brenner, Sana Altaf, "Reducing the number of reconstructions needed for estimating channelized observer performance", Proc. SPIE 10577, Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment, 105770U (7 March 2018); doi: 10.1117/12.2293745; https://doi.org/10.1117/12.2293745
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