In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

Astrid M. Hoving; Jason Voorneveld; Evelien E. de Vries; Erik Groot Jebbink; Michel Versluis; Johan G. Bosch; Nico de Jong; Julia Mikhal; Gert J. de Borst; Cornelis H. Slump

doi:10.1117/12.2293669

6 March 2018 In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent

Astrid M. Hoving, Jason Voorneveld, Evelien E. de Vries, Erik Groot Jebbink, Michel Versluis, Johan G. Bosch, Nico de Jong, Julia Mikhal, Gert J. de Borst, Cornelis H. Slump

Author Affiliations +

Proceedings Volume 10580, Medical Imaging 2018: Ultrasonic Imaging and Tomography; 105800A (2018) https://doi.org/10.1117/12.2293669
Event: SPIE Medical Imaging, 2018, Houston, Texas, United States

Abstract

Introduction: To improve carotid artery stenting (CAS), more information about the functioning of the stent is needed. Therefore, a method that can image the flow near and around a stent is required. The aim of this study was to evaluate the performance of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) in the presence of a stent. Methodology: HFR CEUS acquisitions of a carotid artery phantom, a silicone tube with diameter 8 mm, with and without a stent were acquired at transmit voltages of 2V, 4V and 10V using a Verasonics ultrasound system and C5-2 probe. Different concentrations of ultrasound contrast agent (UCA) were tested in a blood mimicking fluid (BMF). Particle image velocimetry (PIV) analysis was performed on Singular Value Decomposition (SVD) filtered images. Mean and peak velocities, and correlation coefficients were compared between stented and non-stented regions. Also, experimental results were compared with theoretical and numerical models. Results: The averaged experimental mean velocity (0.113 m/s) was significant lower than the theoretical and numerical mean velocity (0.129 m/s). The averaged experimental peak velocity (0.152 m/s) was significant lower than the theoretical and numerical peak velocity (0.259 m/s). Correlation coefficients and averaged mean velocity values were lower (difference of 0.022 m/s) in stented regions compared to non-stented regions. Conclusion: In vitro experiments showed an underestimation of mean and peak velocities in stented regions compared to non-stented regions. However, the microbubbles can be tracked efficiently and the expected laminar flow profile can be quantified using HFR CEUS near and around a stent.

Citation Download Citation

Astrid M. Hoving, Jason Voorneveld, Evelien E. de Vries, Erik Groot Jebbink, Michel Versluis, Johan G. Bosch, Nico de Jong, Julia Mikhal, Gert J. de Borst, and Cornelis H. Slump "In vitro high-frame-rate contrast-enhanced ultrasound particle image velocimetry in a carotid artery stent", Proc. SPIE 10580, Medical Imaging 2018: Ultrasonic Imaging and Tomography, 105800A (6 March 2018); https://doi.org/10.1117/12.2293669

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available