6 March 2018 Semantic segmentation for prostate cancer grading by convolutional neural networks
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Certain pathology workflows, such as classification and grading of prostate adenocarcinoma according to the Gleason grade scheme, stand to gain speed and objectivity by incorporating contemporary digital image analysis methods. We compiled a dataset of 513 high resolution image tiles from primary prostate adenocarcinoma wherein individual glands and stroma were demarcated and graded by hand. With this unique dataset, we tested four Convolutional Neural Network architectures including FCN-8s, two SegNet variants, and multi-scale U-Net for performance in semantic segmentation of high- and low-grade tumors. In a 5-fold cross-validation experiment, the FCN-8s architecture achieved a mIOU of 0.759 and an accuracy of 0.87, while the less complex U-Net architecture achieved a mIOU of 0.738 and accuracy of 0.885. The FCN-8s architecture applied to whole slide images not used for training achieved a mIOU of 0.857 in annotated tumor foci with a multiresolution processing time averaging 11 minutes per slide. The three architectures tested on whole slides all achieved areas under the Receiver Operating Characteristic curve near 1, strongly demonstrating the suitability of semantic segmentation Convolutional Neural Networks for detecting and grading prostate cancer foci in radical prostatectomies.
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Nathan Ing, Nathan Ing, Zhaoxuan Ma, Zhaoxuan Ma, Jiayun Li, Jiayun Li, Hootan Salemi, Hootan Salemi, Corey Arnold, Corey Arnold, Beatrice S. Knudsen, Beatrice S. Knudsen, Arkadiusz Gertych, Arkadiusz Gertych, } "Semantic segmentation for prostate cancer grading by convolutional neural networks", Proc. SPIE 10581, Medical Imaging 2018: Digital Pathology, 105811B (6 March 2018); doi: 10.1117/12.2293000; https://doi.org/10.1117/12.2293000

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