5 March 2018 Phase sensitive optical coherence microscopy for photothermal imaging of gold nanorods
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Proceedings Volume 10591, 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources; 105910E (2018) https://doi.org/10.1117/12.2285816
Event: Second Canterbury Conference on Optical Coherence Tomography, 2017, Canterbury, United Kingdom
Abstract
We describe a swept source based phase sensitive optical coherence microscopy (OCM) system for photothermal imaging of gold nanorods (GNR). The phase sensitive OCM system employed in the study has a displacement sensitivity of 0.17 nm to vibrations at single frequencies below 250 Hz. We demonstrate the generation of phase maps and confocal phase images. By displaying the difference between successive confocal phase images, we perform the confocal photothermal imaging of accumulated GNRs behind a glass coverslip and behind the scattering media separately. Compared with two-photon luminescence (TPL) detection techniques reported in literature, the technique in this study has the advantage of a simplified experimental setup and provides a more efficient method for imaging the aggregation of GNR. However, the repeatability performance of this technique suffers due to jitter noise from the swept laser source.
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Yong Hu, Adrian Gh. Podoleanu, George Dobre, "Phase sensitive optical coherence microscopy for photothermal imaging of gold nanorods", Proc. SPIE 10591, 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources, 105910E (5 March 2018); doi: 10.1117/12.2285816; https://doi.org/10.1117/12.2285816
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