Microscopic and macroscopic spectral peculiarities of cutaneous tumours

Ekaterina Borisova; Tsanislava Genova; Petranka Troyanova M.D.; Ivan Terziev M.D.; Valery Zakharov M.D.; Ivan Bratchenko M.D.; Maria Lomova; Dmitry Gorin; Latchezar Avramov

doi:10.1117/12.2296562

7 December 2017 Microscopic and macroscopic spectral peculiarities of cutaneous tumours

Ekaterina Borisova, Tsanislava Genova, Petranka Troyanova M.D., Ivan Terziev M.D., Valery Zakharov M.D., Ivan Bratchenko M.D., Maria Lomova, Dmitry Gorin, Latchezar Avramov

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Proceedings Volume 10592, Biophotonics—Riga 2017; 1059202 (2017) https://doi.org/10.1117/12.2296562
Event: The Second International Conference "Biophotonics-Riga 2017", 2017, Riga, Latvia

Abstract

Autofluorescence spectral and confocal microscopic measurements were made on different cutaneous neoplastic lesions, namely basal cell carcinoma, squamous cell carcinoma, malignant melanoma, and their dysplastic forms – keratoacantoma, dysplastic nevi and benign lesions related – basal cell papiloma, seboreic keratosa and compound nevi using excitation at 405 nm. Spectroscopic investigations were made on in vivo and ex vivo tissue samples, and confocal microscopy investigations were made on ex vivo and eosin-haematoxilin stained thin slices of the tumours detected. Correlation between the spectral data received and the microscopic features observed was found, related to the morphological and biochemical alterations during neoplasia growth. Specific spectral features observed in each type of lesion investigated on micro and macro level would be presented and discussed.

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Ekaterina Borisova, Tsanislava Genova, Petranka Troyanova M.D., Ivan Terziev M.D., Valery Zakharov M.D., Ivan Bratchenko M.D., Maria Lomova, Dmitry Gorin, and Latchezar Avramov "Microscopic and macroscopic spectral peculiarities of cutaneous tumours", Proc. SPIE 10592, Biophotonics—Riga 2017, 1059202 (7 December 2017); https://doi.org/10.1117/12.2296562

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