Paper
16 April 2018 Effect of iron oxide nanoparticles on the concentration-versus-sizes relation of proteins in the blood plasma and serum, and in model solutions
M. N. Kirichenko, N. A. Bulychev, L. L. Chaikov, M. A. Kazaryan, A. V. Masalov
Author Affiliations +
Proceedings Volume 10614, International Conference on Atomic and Molecular Pulsed Lasers XIII; 106140M (2018) https://doi.org/10.1117/12.2303471
Event: XIII International Conference on Atomic and Molecular Pulsed Lasers, 2017, Tomsk, Russia
Abstract
The effect of iron (III) oxide nanoparticles produced in acoustoplasma discharge with cavitation on the concentration and the sizes of particles in model protein solutions, human blood serum and plasma samples is studied. Dynamic and static light scattering data on size and concentration of particles show that the nanoparticles addition to fibrinogen-thrombin system affects the course of enzymatic reaction. Interaction of nanoparticles with fibrinogen solution (before thrombin addition) does not significantly change the distribution of scattered light intensity on particle sizes. Comparison of the relations of particle sizes and their concentration for fibrinogen solution with and without nanoparticles shows an increase of the slope of size-concentration relation in a log-log scale, which indicates an increase in the concentration of small particles and decrease of big ones. For model solution of fibrinogen with thrombin, initially incubated with iron oxide nanoparticles, the slopes of the size-concentration relation equals to k = –(4.62±0.33) and slightly differs from the slope of the relation for fibrinogen-thrombin system without nanoparticles k=–(4.23±0.28). We believe that changes in the size-concentration relation indicate the interaction of nanoparticles with proteins, which results in gelation rate change.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
M. N. Kirichenko, N. A. Bulychev, L. L. Chaikov, M. A. Kazaryan, and A. V. Masalov "Effect of iron oxide nanoparticles on the concentration-versus-sizes relation of proteins in the blood plasma and serum, and in model solutions", Proc. SPIE 10614, International Conference on Atomic and Molecular Pulsed Lasers XIII, 106140M (16 April 2018); https://doi.org/10.1117/12.2303471
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KEYWORDS
Nanoparticles

Particles

Plasma

Blood

Proteins

Iron

Oxides

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