Precise sample preconcentration based on plasmon-assisted optical manipulation for a bead-based Raman biosensor

Min Jiang; Guanghui Wang; Xuping Zhang

doi:10.1117/12.2295661

10 January 2018 Precise sample preconcentration based on plasmon-assisted optical manipulation for a bead-based Raman biosensor

Min Jiang, Guanghui Wang, Xuping Zhang

Author Affiliations +

Proceedings Volume 10618, 2017 International Conference on Optical Instruments and Technology: Advanced Optical Sensors and Applications; 106180F (2018) https://doi.org/10.1117/12.2295661
Event: International Conference on Optical Instruments and Technology 2017, 2017, Beijing, China

Abstract

We developed a novel lab-on-a-chip device with the capability of rapidly pre-concentrating for Raman detection that use gold bead as the solid carrier of biomolecules. The device combines an array of patterned plasmonic surface (i.e. gold nano-ellipses), as the bead manipulation element. The purpose of gold bead manipulation is to provide sample pre-concentration in close proximity of the Raman detecting region. In the presence of an external uniform electric field, the gold ellipses create local electric field gradients (which is usually called hot spots) that capture the gold beads. The location of hot spots within a plasmonic nanostructure is polarization dependent, and inhomogeneous electric field between two adjacent nano-ellipses perpendicular to each other leads to highly unbalanced trap potential that give the chance of transferring trapped particles in a given direction through rotating the polarization. Nano-optical conveyor belts with staircase pattern of nano-ellipses were arranged with their terminus collected at detection area to gather biomolecules. With the capacity to transfer biomolecules precisely, our design offers an attractive scheme for rapid, high throughput and highly sensitive sensing of low abundance analytes.

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Min Jiang, Guanghui Wang, and Xuping Zhang "Precise sample preconcentration based on plasmon-assisted optical manipulation for a bead-based Raman biosensor", Proc. SPIE 10618, 2017 International Conference on Optical Instruments and Technology: Advanced Optical Sensors and Applications, 106180F (10 January 2018); https://doi.org/10.1117/12.2295661

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KEYWORDS

Polarization

Particles

Raman spectroscopy

Gold

Optical manipulation

Plasmonics

Lab on a chip

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