In the recent years, lasers around 1.6 μm are attracted much attention since their wavelengths fit the atmospheric transmission window and can be used for applications in a range of fields including laser radar, gas sensing, and free-space communications. As one of the lasing wavelengths of an Er:YAG medium is just located in the 1.6 μm region, such a laser has been gaining more and more extensive applications in the near infrared. Until now, rare literatures have been found in the MOPA (Master Oscillator Power Amplifier) study of a 1.617 μm Er:YAG laser because the effect of upconversion will become greater while a higher doping concentration is adopted. In this study, we theoretically analyze the amplification features of a 1.617 μm Er:YAG seed laser by using a multiple MOPA configuration. In the simulation, a kinetic model is established to investigate how the doping concentration, crystal length, and pump power affect the amplification efficiency of a seed laser. The results would be helpful to construct a feasible 1.617 μm laser system.