As the Gulf of Mexico has experienced major environmental hazards in the recent past, e.g. the BP oil spill in 2010, landfall of major hurricanes, and the frequent outbreak of red tide (Karenia brevis), it is required to evaluate possible alterations in the water quality and biogeochemical balance of this partially enclosed waterbody. Chlorophyll concentrations (Chl-a) and sea surface temperature (SST) Level-2 data from five satellites during the period from 2009 to 2013 were analyzed for their spatial, temporal, and inter-annual variability. Based on the evaluation of data from 24 transects from the West Florida Shelf (WFS), highest Chl-a was observed for the sector from St. Petersburg to Sanibel Island. Additionally, high Chl-a was observed for the Big Bend region, particularly during the spring and early summer. SST distribution also closely followed Chl-a distribution, even though occasional uptick in SST values were noticed from the inner continental shelf even during high primary productivity. Furthermore, between 2010 and 2011, monthly Chl-a and SST varied across the shelf significantly and can be due to the incursion of the Loop Current towards the WFS, as suggested by Weisberg et al. (2014).