8 August 1989 Modeling Of The Laser-Induced Ablation And Thermal Damage Of Biological Tissue
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Detailed calculations of the thermal response and ablation of biological tissue exposed to 10p laser radiation are presented. For most of the calculations shown, tissue response was modeled using generalized computer codes that were originally developed to model the laser-induced response of a variety of non-biological materials. The models are applicable at any wavelength for which the absorption cross section in the tissue is large compared to the scattering cross section. In this initial study, soft tissue has been modeled as a single component material with thermal and optical properties very similar to that of water. The predominant phenomena treated are in-depth laser absorption, thermal conduction, and surface vaporization. In-depth thermal damage of tissue is calculated by incorporating into the codes a reaction for the thermal denaturation of tissue protein. Model calculations are presented for exposures ranging from low power CW exposures of a few watts per cm and exposure times of tens of seconds to single-pulse exposures with peak irradiances of several megawatts per cm2 and microsecond exposure durations. Where possible, model predictions are compared to available experimental data and the implications of the comparisons are discussed. Recommendations for future modeling improvements are also presented.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
David I Rosen, Leslie A Popper, "Modeling Of The Laser-Induced Ablation And Thermal Damage Of Biological Tissue", Proc. SPIE 1064, Thermal and Optical Interactions with Biological and Related Composite Materials, (8 August 1989); doi: 10.1117/12.951944; https://doi.org/10.1117/12.951944

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