13 June 1989 Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers
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Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.977998
Event: OE/LASE '89, 1989, Los Angeles, CA, United States
Abstract
Various different photosensitizers were compared to Photofrin® II with respect to their potential for causing direct tumor cell inactivation and/or vascular damage. GaCl-phthalocyanine of mixed sulfonation, while being 10 x more efficient than Photofrin® II in tumor cell inactivation, caused equal vascular photosensitization. Monosulfonated AlC1-phthalocyanine, on the other hand, was sparing to the vasculature, while still exhibiting good tumor cell effects. Large differences in vascular photosensitization were also observed with tetra- and monosulfonated tetraphenylporphines.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Barbara W. Henderson, Barbara W. Henderson, Gwendolyn Farrell, Gwendolyn Farrell, } "Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); doi: 10.1117/12.977998; https://doi.org/10.1117/12.977998
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