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11 September 1989 Creation And Healing Of Vascular Lesions Produced By A Mid-Infrared Laser
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Pulses of laser light in the 2 micron range should ablate tissue in a manner similar to the 10.6 micron CO2 laser with the added advantage of efficient transmission through flexible quartz fibers. We performed an evaluation of a pulsed 2.15 micron laser system with regard to the laser's potential for atherosclerotic vascular applications. In vitro, we lasered fresh human calcific atherosclerosis. Approximately 10 pulses of the THC:YAG at 900 mJ/pulse penetrated a 5 mm thick plaque and caused approximately 80 micron depth of thermal damage. For the in vivo testing, fourteen rabbits underwent aortotomy and backwall exposure to 5 pulses of the THC:YAG laser at 450 millijoules per pulse in order to evaluate the thrombogenic and healing potential of 2.15 micron lasered vessel walls. At time of sacrifice, all aortas were patent. Immediately after treatment, a 60-80 micron deep area of dessicated tissue surrounded the lasered crater. A 40 micron thick thrombi covered the damaged tissue. Healing of the lasered tissue consisted of neovascularization and fibroblast ingrowth from the periphery as well as endothelial cell ingrowth from the surrounding intima. Our results indicate that the pulsed 2.15 micron THC:YAG system deserves further consideration for angioplasty applications.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mehmet C. Oz, Michael R. Treat, Stephen L. Trokel, and Roman Nowygrod "Creation And Healing Of Vascular Lesions Produced By A Mid-Infrared Laser", Proc. SPIE 1066, Laser Surgery: Advanced Characterization, Therapeutics, and Systems, (11 September 1989);

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